Ulcerative colitis (UC), as defined by the US National Library of Medicine, is a chronic disease that causes the onset of inflammation and sores—better known as ulcers—within the lining of the rectum and the colon. As part of the umbrella of inflammatory bowel disease (IBD), it’s one of several conditions that affect the bowels through inflammation. This chronic disease lasts over the patient’s lifetime and develops further over time. Ulcerative colitis is a debilitating disease and has the potential to spiral towards life-threatening seriousness. Currently, there is no known cure for this disease, and long-term remission can only be achieved through modern treatment and medication.
Some of the earliest histories of inflammatory bowel disease stem from the discovery of ulcerative colitis. While the specifics of the dates remain subject to discussion among historians, the symptoms that have been recognized as hallmarks of ulcerative colitis have dated back to ancient Greece.
Sir Samuel Wilks first coined the term “ulcerative colitis” in 1859 when he described a case that’s remarkably similar to how the disease is known today. Sir William Hale White described ulcerative colitis as a disease without a known cause, and the term became accepted in the medical field.
Ulcerative colitis itself targets the gastrointestinal tract, much like the other diseases that fall under the name inflammatory bowel disease. The condition is typically found in the large intestine or the colon, which is where the nutrients and water from undigested food are absorbed, and waste products are brought through to the rectum and anus to create feces. When a person has ulcerative colitis, the presence of inflammation and ulcers along the colon’s inner lining causes the associated symptoms of significant abdominal pain, diarrhea, and rectal bleeding.
The inflammation typically begins around the rectal area before spreading upward in the gastrointestinal tract. As inflammation spreads, the cells on the bowel lining begin to die, which creates ulcers. These ulcers produce pus and mucus, sometimes even bleeding, causing pain in the abdomen, and the need to rapidly and frequently move your bowels.
The extent of the disease differs between patients. Sometimes it may involve only the rectum; for others, it may spread throughout the entire colon. Even the severity of the disease may vary among patients. Some may experience minimal symptoms, while others may develop severe complications.
In many ways, ulcerative colitis is quite similar to Crohn’s disease, as they often develop around the same age, affect similar demographic groups, and exhibit similar symptoms. Both also have no known causes and similar contributing factors. However, ulcerative colitis is typically limited to a person’s colon, whereas Crohn’s disease can affect different areas along the gastrointestinal tract, including areas beyond it, such as the liver, the joints, eyes, and skin. Crohn’s disease patients also typically have healthy regions along with inflamed areas of the intestine. But ulcerative colitis patients experience continuous inflammation along their colon. Finally, ulcerative colitis also affects the colon’s innermost lining, whereas Crohn’s disease can move through the layers of the bowel walls.
Together, both diseases fall under the name of inflammatory bowel disease. Roughly 750,000 people in the United States are diagnosed with ulcerative colitis. To date, there is no known cure for the disease, though proper treatment and medical care can dramatically improve a person’s quality of life.
The symptoms of ulcerative colitis vary between people, as well as the severity of these symptoms and additional complications. Roughly half of people diagnosed with ulcerative colitis experience relatively mild symptoms. Approximately 10% of affected individuals may have very severe symptoms, but this varies by how far the disease and the inflammation have progressed in their colon. In general, patients who have mild symptoms experience inflammation restricted to the rectum and a short colon segment adjacent to it. They often have a far better prognosis than patients with more widespread inflammation over their colon.
Ulcerative colitis is a disease that manifests itself in cycles. Flare-ups are instances where symptoms are followed by periods of remission wherein the symptoms fade or disappear. Patients will go through these cycles for the rest of their lives. With proper treatment and medical care, these periods of remission can last longer before the next flare-up occurs. The period of remission could last months or even years. However, due to the lack a cure for this disease, eventually the symptoms will return in some form. The periods of flare-ups and remissions are still unpredictable for the most part. The disease’s unpredictability makes it difficult to evaluate whether or not the current treatment that a patient is on is working.
The disease can manifest at roughly any age, though the majority of people are diagnosed around their mid-30s. A small percentage of the affected population first experience their symptoms in their 60s or 70s. It’s essential to pay close attention to the presence of commonly recognized signs of ulcerative colitis and to make sure that you contact a healthcare provider if you experience them.
Some of the most frequent signs and symptoms include:
Beyond gastrointestinal tract-related symptoms, other issues can appear as a result of the damage that the other symptoms have caused. The symptoms affect the quality of one’s life. These include:
Complications may arise from ulcerative colitis, especially when symptoms go untreated or uncontrolled. Inflammation can permanently damage the colon lining itself. Some long-term complications of ulcerative colitis include:
The lack of a specific cause, along with the symptoms and complications manifesting in patients in several ways, leads doctors to define different types of ulcerative colitis, which makes it even more important to diagnose and treat the disease correctly. The different types of ulcerative colitis are:
Extensive Colitis – In this type of ulcerative colitis, the entire colon becomes affected with a continuous inflammation, beginning at the rectum beyond the splenic fixture. Symptoms include appetite loss, abdominal pain, weight loss, and bloody diarrhea.
The exact causes of ulcerative colitis remain largely unknown, although considerable medical research confirmed that it may be the result of several factors. To date, there has been no convincing evidence that the disease is caused by infection or is contagious.
Environmental factors – Because it’s been considered as a form of immune disorder, bacteria, viruses, and antigens are considered as risk factors for ulcerative colitis. Some studies suggest that certain things in the environment increase the likelihood of someone getting ulcerative colitis. However, the overall environmental risk is low. Some studies also indicate that nonsteroidal anti-inflammatory drugs or antibiotics could also increase the risk. A high-fat diet may also put people at risk of developing the disease. Certain foods, stress, and emotional distress are also said to be a trigger, but to date, doctors have not found conclusive evidence that proves this is true.
The different varieties of ulcerative colitis, along with the varying degrees of severity in the disease’s symptoms, make it necessary for doctors to make a correct diagnosis. Most healthcare providers should conduct a series of medical tests and exams, not just to make the diagnosis, but also to rule out other inflammatory bowel disorders or other causes of the symptoms.
Blood tests – A blood test may be used to seek out signs of anemia or a low blood count. There also may be a need for specialized antibody tests or tests to determine a high level of C-reactive proteins.
The use of medication can suppress inflammation of the colon and give the body’s tissues more time to heal. They can also be used to suppress the severity of symptoms that cause diarrhea, bleeding, and abdominal pain. With proper administration, medications can also help decrease flare-ups of symptoms. Some of these medications include mesalamine, sulfasalazine, balsalazide, and olsalazine. Some doctors may also recommend corticosteroids, antibiotics, and biologics, but these will depend on each individual’s symptoms.
Diet & Lifestyle:
No evidence supports treatment solely through dietary modification, but it’s still recommended for patients with ulcerative colitis to stay on a healthy, balanced diet. Food should be rich in fruits, vegetables, grains, beans, nuts, lean meats, fish, and eggs. It’s also recommended to eat four to six small meals a day and to remain hydrated. Drink slowly and avoid consuming products that may cause patients to ingest gas, including carbonated drinks.
Therapy and Procedures:
Living with a chronic illness such as ulcerative colitis may call for more specialized treatment, especially when symptoms get worse. Patients with more severe symptoms of ulcerative colitis may need to be hospitalized. A sudden and severe onset of acute symptoms of ulcerative colitis, such as uncontrolled bleeding, toxic megacolon, and perforation of the colon, may require emergency surgery.
These surgeries could be:
Proctocolectomy with end ileostomy, which is the removal of the rectum, colon, and anus. An external ostomy is created.
To date, there is still no known cure for ulcerative colitis. Researchers are still conducting studies and clinical trials to test new treatments, interventions, and tests to detect and manage the disease.
In researching both causes and treatments for ulcerative colitis, it’s critically important to look into comprehensive patient medical histories. If doctors are more aware of what could be triggering symptoms internally, genetically, or environmentally, they may be able to take further steps towards finding a cure for the disease. Comprehensive digital medical records aid them greatly in this regard, allowing them to keep track of their patients and keep a close eye on the changes in their situations as well as what led them towards the diagnosis of the disease.
Doctors continue to seek out biological agents that are also potentially more effective in treating ulcerative colitis with fewer side effects. Today there remain many questions to be answered around the cause and the mechanism of ulcerative colitis inflammation. Development of newer and safer medications continues, as well as improvements in surgical procedures to improve the patient’s health and future quality of life.
People with ulcerative colitis who want to contribute to research can sign up for a PicnicHealth account to contribute their anonymized medical data to inflammatory bowel disease research.