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IBD vs IBS: What's the difference?

Because they have similar initials, it can be confusing understanding the difference between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). 

At first glance to many non-specialists, the two diseases might seem to be the same, as they affect the same area of the body and have similar symptoms between them. But while the two conditions may both affect the digestive tract, there are very significant differences between them.

What is inflammatory bowel disease?

Inflammatory bowel disease is a broad term that refers to several inflammatory conditions that affect the gastrointestinal tract, particularly the colon and the small intestine. The most well-known varieties of IBD are Crohn’s disease and ulcerative colitis, though there are some other lesser-known types of IBD as well. While IBD is genetic for many patients, there is no single gene that has been shown to cause it. The symptoms are mild for many sufferers, but the severe ones can be extremely life-threatening and may require emergency surgery.

What is irritable bowel syndrome?

On the other hand, irritable bowel syndrome is a disorder itself. It’s found in the large intestine or colon just like IBD, but it’s referred to as a type of disturbance in the bowel’s functions. It makes life very difficult for those who have it, making them uncomfortable and affecting their daily lives. Its symptoms range from mild to debilitating. People who have IBS are also more likely to have fibromyalgia, chronic fatigue syndrome, chronic pelvic pain, and TMJ disorder. IBS affects roughly 10% to 15% of adults within the US, with more women affected than men.

What’s the same, and what’s different?

While IBD and IBS may have similarities, they are very different from each other. There’s a lot between them that is quite different.

Consider the following:

  • Symptoms - IBD manifests as frequent or urgent bowel movements, bloody stool, diarrhea, lack of appetite, weight loss, and joint, skin, and eye problems. Meanwhile, IBS manifests in abdominal pain and cramping, bloating, gassiness, diarrhea, or constipation.
  • Complications - Common complications of IBD include stenosis, abscesses, bowel obstructions, and colon cancer. On the other hand, IBS can be troublesome and impair quality of life, but it doesn’t lead to life-threatening complications. 
  • Pain - Abdominal pain associated with IBD occurs just about anywhere in the abdomen. Health experts often rely on the pain’s location to determine what type of IBD the patient may be suffering from. With IBS, pain is often spread throughout a wide area. The pain intensifies when eating, and when gas is present in the GI tract.
  • Causes - Both IBD and IBS don’t have specific causes. However, IBD is thought to be a result of a malfunctioning immune system that attacks healthy tissue in the intestines, rather than intruding viruses or bacteria. Genetic disposition is also considered among its causes. Meanwhile, IBS is thought to be a result of hyper-reactivity towards bacterial infections in the gut.
  • Diagnosis - IBD is diagnosed through specialized diagnostic imaging, while IBS doesn’t show signs during a colonoscopy or similar exams. 

While both disorders appear comparable at first, it’s clear that IBD is the more serious of the two. It’s incredibly important for doctors to correctly discern which problem the patient has so that they may be able to provide the best care.

A comprehensive patient history aids diagnosis greatly, and digital patient records can do just that. Visit PicnicHealth.com to learn more about how to access your electronic health records.

LC-FAOD Odyssey: A Preliminary Analysis, presented at INFORM 2021

Data from real-world medical records:

(from 13 patients with LC-FAOD)

16 yrs old

Median age at enrollment

38% Female

15 providers / patient

7.5 years of data / patient

Data from patient-reported outcome (PRO) survey

(from 13 patients with LC-FAOD)


patients onboarded to platform


medical visits processed


facilities provided medical records


healthcare providers


research programs


published posters and manuscripts


partnerships withtop 30 pharma

New Research

Discover how PicnicHealth data powered medical research in 2021

Keeping Patients at the Center

This year, experts from PicnicHealth joined podcasts, webisodes, virtual summits and much more to speak to the importance of patient-centric approaches when building complete, deep real-world datasets.


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